A-Ret Gel (Tretinoin) 0.1%, 20 g: profile, composition and research
Reference page for A-Ret Gel (Tretinoin) 0.1%, 20 g. Active substance: Третиноин / Tretinoin.
- What it is: tretinoin, a topical retinoid related to vitamin A.
- Presentation: 0.1% gel, 20 g tube.
- Status: prescription-only medicine.
- Research: work on topical retinoids in acne, links below.
- Where to buy: APV Pharmacy (price and availability there).
Key facts
| Active substance | Tretinoin |
|---|---|
| Form | Gel for topical use |
| Strength | 0.1% |
| Pack size | 20 g tube |
| Category | Prescription medicine |
| Article (SKU) | ARET-01-20G |
What tretinoin is
Tretinoin is a retinoid, a substance related to vitamin A. In dermatology it has been used topically for several decades.
In A-Ret gel it is present at a concentration of 0.1 percent. That is one of the higher tretinoin concentrations among topical forms, so the product is matched to a specific skin rather than chosen from online advice.
The product is supplied in a 20 g tube and is applied to the skin only.
How tretinoin acts on the skin
Cell renewal
Tretinoin speeds up the natural cycle of epidermal cell renewal. The horny layer turns over faster and older cells linger less on the surface.
Pores
Because cells are shed faster, they do not accumulate in the openings of hair follicles. This reduces the chance of pores becoming blocked.
Inflammation
Retinoids also influence inflammatory processes in the skin. That is why the first weeks of use are sometimes accompanied by a temporary increase in skin reaction.
Approved uses
The prescribing information lists topical treatment of acne vulgaris. Tretinoin does not kill bacteria directly: its task is to normalise the process that makes pores clog.
The result develops gradually and not at once. A temporary flare-up at the start of use is an expected part of the course, not a sign that the product does not suit the patient.
The duration and the regimen are set by a doctor or dermatologist. Choosing a high concentration on one's own is not advisable.
Use and skin care
Tretinoin increases the skin's sensitivity to ultraviolet light. During treatment, sun exposure is limited and protective products are used.
The gel is applied only to dry, unbroken skin, avoiding the eyes, lips, corners of the nose and mucous membranes. If the skin is irritated, sunburned or affected by eczema, application is postponed.
Using exfoliating or alcohol-based products, or preparations with benzoyl peroxide, at the same time may increase irritation. How to combine such products is best discussed with a doctor or pharmacist.
Published research
Primary sources, verified against PubMed:
- An Updated Review of Topical Tretinoin in Dermatology: From Acne and Photoaging to Skin Cancer., PubMed 41302994 (Journal of clinical medicine, 2025).
- Topical Retinoids in Acne Vulgaris: A Systematic Review., PubMed 30674002 (American journal of clinical dermatology, 2019).
- Guidelines of care for the management of acne vulgaris., PubMed 38300170 (Journal of the American Academy of Dermatology, 2024).
Listed for reference. Publication of a study is not a claim about this particular product.
Precautions
- This is a prescription medicine. The concentration and the regimen are set by a doctor or dermatologist.
- For topical use only. The gel is not taken by mouth.
- Tretinoin increases the skin's sensitivity to the sun, so protection from ultraviolet light is needed during treatment.
- It is not applied to broken, sunburned or inflamed skin, or near the eyes, lips and mucous membranes.
- Use during pregnancy, when planning pregnancy or while breastfeeding is discussed with a doctor individually.
- In marked or persistent irritation, swelling or signs of allergy, use is stopped and a doctor is consulted.
Frequently asked
Is A-Ret Gel a prescription medicine?
Yes. Tretinoin is a medicinal retinoid and should be used as directed by a physician.
Can the gel be applied more often to speed up the result?
No. More frequent or thicker application increases irritation without bringing the result closer.
Does the gel suit any skin?
No. A concentration of 0.1 percent is considered high, and its suitability is assessed by a physician.
Where does the order ship from?
Shipping and customs handling are described on the APV Pharmacy delivery page.