Acotiamide (Akofide) 100 mg, 100 tablets: profile, composition and research
Reference page for Acotiamide (Akofide) 100 mg, 100 tablets. Active substance: Акотиамид / Acotiamide.
- What it is: acotiamide, a medicine that stimulates gastrointestinal motility.
- Presentation: 100 mg tablets, 100 tablets per pack.
- Status: prescription-only medicine.
- Research: reviews and meta-analyses in functional dyspepsia, links below.
- Where to buy: APV Pharmacy (price and availability there).
Key facts
| Active substance | Acotiamide |
|---|---|
| Form | Tablets |
| Strength | 100 mg per tablet |
| Pack size | 100 tablets |
| Category | Prescription medicine |
| Article (SKU) | 8798653 |
What acotiamide is
Acotiamide is a substance developed in Japan and classed as a stimulant of gastrointestinal motility. It is registered there for functional dyspepsia and is sold under several brand names, Akofide among them.
Functional dyspepsia is a condition in which a person is troubled by heaviness and fullness after eating, bloating and early satiety, while examination finds no clear organic cause.
The product comes as 100 mg tablets. A pack of 100 tablets is meant for prolonged use, which matches the chronic nature of the condition.
How acotiamide works
The target
Acotiamide inhibits the enzyme acetylcholinesterase. That enzyme breaks down acetylcholine, the messenger that carries signals from nerves to the muscle of the stomach wall.
What follows
When the enzyme works less actively, more acetylcholine remains near the nerve endings. The stomach wall contracts more vigorously and emptying speeds up, which eases the sense of fullness.
Difference from other prokinetics
Acotiamide's mechanism is not tied to dopamine receptor blockade, unlike some medicines in this group. That profile explains why it was studied specifically in functional disorders of the stomach.
Approved uses
The prescribing information lists the symptoms of functional dyspepsia: fullness after eating, bloating and early satiety in adult patients.
The decision to use it is made by a doctor after examination. A feeling of heaviness in the stomach can have various causes, and some of them call for entirely different management, so self-diagnosis has no place here.
Choosing the treatment, watching its tolerability and ordering further tests are the gastroenterologist's task.
What to keep in mind
The medicine is intended for adults. It is not recommended during pregnancy or breastfeeding, and a doctor decides on each individual case.
Among possible reactions, studies mention digestive changes, liver test abnormalities and blood-related findings. Unusual symptoms call for medical supervision.
Tell your doctor about every medicine you take: drugs with the opposite effect on acetylcholine can weaken acotiamide, and other combinations need assessment.
Published research
Primary sources, verified against PubMed:
- Acotiamide and Functional Dyspepsia: A Systematic Review and Meta-Analysis., PubMed 35070565 (Cureus, 2021).
- Profile of acotiamide in the treatment of functional dyspepsia., PubMed 27103837 (Clinical and experimental gastroenterology, 2016).
- Evidence-based clinical practice guidelines for functional dyspepsia 2021., PubMed 35061057 (Journal of gastroenterology, 2022).
Listed for reference. Publication of a study is not a claim about this particular product.
Precautions
- This is a prescription medicine. Prescribing and monitoring belong to a physician.
- Heaviness and bloating call for examination: the causes of such symptoms differ.
- The medicine is intended for adults. Use during pregnancy or breastfeeding is not recommended and is discussed with a doctor.
- Studies noted changes in liver tests and blood findings, so monitoring is ordered by a physician.
- Tell your doctor about every other medicine you take: interactions are possible.
- Unusual symptoms while taking the medicine should be reported to a doctor.
Frequently asked
Is Akofide a prescription medicine?
Yes. It is a prescription medicine and is not intended for use on one's own.
Does acotiamide help with ordinary indigestion?
It was studied in functional dyspepsia, that is, with an established diagnosis. Occasional indigestion and other conditions need separate assessment by a doctor.
Why does this page not give a dosing schedule?
The dose and the duration depend on the diagnosis and the patient's condition. That is a physician's decision, not a reference page's.
Where does the order ship from?
Shipping and customs handling are described on the APV Pharmacy delivery page.