Carpronium chloride solution for external use 5%, 30 ml, 12 vials: profile, composition and research

Reference page for Carpronium chloride solution for external use 5%, 30 ml, 12 vials. Active substance: Карпрония хлорид / Carpronium chloride.

Key facts

What carpronium chloride is

Carpronium chloride is the active substance of a liquid product for external use, supplied at a concentration of 5%. It is a clear solution with a greenish tint, meant to be applied to the skin.

The presentation is 30 ml vials, 12 vials per pack. The solution is applied to the scalp, so this is local action rather than a tablet or an injection.

In dermatology solutions of this kind are used in hair loss and in certain conditions of the scalp. This is a prescription product: use is agreed with a dermatologist.

How carpronium chloride acts

Widening of blood vessels

Carpronium chloride causes local widening of the skin capillaries. In animal experiments its effect on the microcirculation was studied by intravital videomicroscopy, which supports a vascular component of action.

Blood flow and nourishment of the bulbs

Increased blood flow raises the delivery of oxygen and nutrients to the hair bulbs. The solution also affects the permeability of the skin, so active molecules penetrate more deeply towards the hair roots.

Action on the follicles

By improving metabolism in the tissues it creates conditions for hair bulbs that are in an inactive phase. This concerns support for natural processes rather than an immediate result.

Approved uses

In dermatological practice the solution is mentioned in various forms of alopecia, in dry seborrhoea of the scalp, and in vitiligo as part of a combined approach.

The method of use differs with the condition: in hair loss and seborrhoea the solution is applied to the affected areas or spread over the whole surface of the scalp; in vitiligo it is applied strictly to the areas without pigment.

The particular frequency of application and the length of treatment are set by a physician. A reference page contains no prescriptions and does not replace a dermatologist's advice.

What the research shows

Publications on carpronium chloride are few. In a rat experiment its effect on the microcirculation of the mesentery was assessed by intravital videomicroscopy, which supports an influence on small vessels.

Clinical guidelines on the treatment of hair loss in men and women list a number of topical agents, but carpronium chloride is not among the main, best-studied options.

Cases of unwanted effects have also been described: swallowing the solution by accident produced a cholinergic crisis. This underlines that the product is intended for external use only. The data are not sufficient to draw conclusions about its advantages.

Published research

Primary sources, verified against PubMed:

• Effects of carpronium chloride on the microvascular blood flow in rat mesentery using intravital videomicroscopy., PubMed 16543627 (Clinical hemorheology and microcirculation, 2006).
• Cholinergic crisis caused by ingesting topical carpronium chloride solution: A case report., PubMed 34030906 (The American journal of emergency medicine, 2021).
• Guidelines for the diagnosis and treatment of male-pattern and female-pattern hair loss, 2017 version., PubMed 29863806 (The Journal of dermatology, 2018).
• [Effects of Skin Environmental Changes by Steam Towel, Ethanol, l-Menthol and Carpronium on the Drug Behavior in the Minoxidil Nanoparticles-applied Mice]., PubMed 36047213 (Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2022).

Listed for reference. Publication of a study is not a claim about this particular product.

Precautions

• This is a prescription medicine. Prescribing and the method of application belong to a dermatologist.
• For external use only. Taking it by mouth is dangerous: a cholinergic crisis after accidental swallowing of the solution has been reported.
• Do not let the solution get into the eyes. After accidental contact, rinse them at once with plenty of clean water.
• It is not started in hypersensitivity to the components of the solution.
• Use during pregnancy or breastfeeding is discussed with a doctor individually.
• If marked reactions appear after application, such as heavy sweating, chills or nausea, stop using it and consult a doctor.

Frequently asked