Konaqueen 150 (Fluconazole) 150 mg, 100 tablets: profile, composition and research
Reference page for Konaqueen 150 (Fluconazole) 150 mg, 100 tablets. Active substance: Флуконазол / Fluconazole.
- What it is: fluconazole, an oral antifungal agent of the triazole group.
- Presentation: 150 mg tablets, a pack of 100 tablets.
- Status: prescription-only medicine used under medical supervision.
- Research: work on candidiasis, cryptococcosis and prophylaxis, links in the section below.
- Where to buy: APV Pharmacy (price and availability there).
Key facts
| Active substance | Fluconazole |
|---|---|
| Form | Tablets for oral use |
| Strength | 150 mg per tablet |
| Pack size | 100 tablets |
| Category | Prescription antifungal medicine |
| Article (SKU) | KONA-FLU-150-100 |
What fluconazole is
Fluconazole belongs to the triazole antifungals. It is a synthetic compound that restrains the growth of fungi and yeasts, including various Candida species. Each tablet carries 150 mg of the active substance, and the pack of 100 tablets is intended for extended courses taken under medical supervision.
Unlike many antifungal agents, fluconazole is well absorbed from the gut and distributed through tissues and body fluids. It reaches the cerebrospinal fluid, saliva, sputum and skin, which is why it is used not only for surface mycoses but also for deep fungal infections.
Regular intake builds a stable concentration in the blood, and the substance leaves the body mainly with urine. That is one reason why kidney function is assessed before treatment begins.
How fluconazole acts
The fungal cell wall
The medicine targets an enzyme involved in building ergosterol, an essential part of the fungal cell membrane. Without it the membrane loses strength and can no longer hold the contents of the cell properly.
Selectivity
The fungal enzyme differs from its human counterpart, so the medicine works mostly on the pathogen and affects the body's own cells to a lesser degree. This is the basis of its comparatively good tolerability.
Fungistatic action
Fluconazole first of all restrains fungal multiplication rather than destroying the organism instantly. Clearing tissues fully depends on the patient's immune response and takes time, which is why a course should be completed.
Spectrum
Yeasts of the genus Candida and Cryptococcus are the most susceptible. Moulds such as Aspergillus are resistant to fluconazole, and other drugs are used against them.
Approved uses
The prescribing information lists candidiasis at different sites: vaginal candidiasis, oropharyngeal and oesophageal candidiasis and infection of other mucous membranes, as well as systemic candidiasis, including candidaemia in patients with reduced immunity.
Cryptococcosis is listed separately, cryptococcal meningitis among it. There the medicine is used both as part of the main treatment and to prevent relapse in people with HIV infection and other immunodeficiencies.
Preventive indications cover fungal infections in high-risk patients: after transplantation, during prolonged neutropenia and after courses of chemotherapy. A physician decides on such use after examination.
Fluconazole is not a medicine for self-treatment. The dose, the length of the course and the need for laboratory monitoring are all set by a doctor, taking into account the pathogen and the patient's condition.
What the research shows
Fluconazole is thoroughly studied, having been in clinical use since the late 1980s. A review of accumulated experience in candidiasis describes it as one of the standard oral antifungals for yeast infections of varying severity.
A recent network meta-analysis of randomised trials in uncomplicated vulvovaginal candidiasis compares topical with oral regimens and single-day with multiple-day fluconazole treatment. It supports comparable effectiveness for some of these approaches, though it does not replace a physician's decision.
In cryptococcal meningitis and in prophylaxis for neutropenic patients, fluconazole appears in large randomised trials and international guidelines. It is worth noting that much of this research was conducted in particular patient groups, and data on long courses outside those groups remain limited.
Published research
Primary sources, verified against PubMed:
- Fluconazole for the treatment of candidiasis: 15 years experience., PubMed 15482201 (Expert review of anti-infective therapy, 2004).
- Diagnosis and management of cryptococcal meningitis in HIV-infected adults., PubMed 38014977 (Clinical microbiology reviews, 2023).
- Treatment of uncomplicated vulvovaginal candidiasis: topical or oral drugs? Single-day or multiple-day therapy? A network meta-analysis of randomized trials., PubMed 40157526 (American journal of obstetrics and gynecology, 2025).
- Global guideline for the diagnosis and management of candidiasis: an initiative of the ECMM in cooperation with ISHAM and ASM., PubMed 39956121 (The Lancet. Infectious diseases, 2025).
Listed for reference. Publication of a study is not a claim about this particular product.
Precautions
- This is a prescription medicine: prescribing, dosing and monitoring belong to a physician.
- It is not used in case of hypersensitivity to fluconazole or other azole antifungals.
- Fluconazole prolongs the QT interval, so care is needed in heart rhythm disorders and when related medicines are taken.
- It may affect the liver, so during long courses a doctor checks blood values.
- The dose is adjusted in impaired kidney function; tell your doctor about kidney and liver conditions.
- During pregnancy and breastfeeding, use is possible only on a doctor's decision.
- Tell your doctor about every other medicine you take: interactions are possible, including with anticoagulants.
Frequently asked
Is Konaqueen 150 a prescription medicine?
Yes. It is a prescription antifungal used under medical supervision.
Why does this page not give a dosing schedule?
The dose and the length of the course are set by a physician: they depend on the type of infection, the severity of the condition and kidney function.
What if a course is interrupted?
Stopping early allows the infection to return. Tell your doctor and clarify the next steps with them.
Where does the order ship from?
Shipping and customs handling are described on the APV Pharmacy delivery page.