Melsmon (Placental extract) 2 ml, 10 ampoules: profile, composition and research
Reference page for Melsmon (Placental extract) 2 ml, 10 ampoules. Active substance: Гидролизат плаценты человека / Human placental extract.
- What it is: Melsmon, a Japanese medicine based on a hydrolysate of human placenta.
- Presentation: solution in 2 ml ampoules, 10 ampoules per pack.
- Status: prescription-only medicine, administered by a healthcare professional.
- Research: work on climacteric symptoms and on the biological effects of placental extracts, links below.
- Where to buy: APV Pharmacy (price and availability there).
Key facts
| Active substance | Hydrolysate of human placenta |
|---|---|
| Form | Solution for injection |
| Strength | 2 ml per ampoule |
| Pack size | 10 ampoules |
| Category | Prescription medicine |
| Article (SKU) |
What Melsmon is
Melsmon is a Japanese medicine obtained from human placenta. The raw material is purified and hydrolysed: large proteins are split into short fragments, so the solution contains peptides, free amino acids and other low-molecular compounds.
The medicine comes in 2 ml ampoules as a solution that needs no preparation, 10 ampoules per pack. The solution is administered by healthcare professionals; in Japan the product is classified as a prescription medicine rather than a cosmetic.
The name Melsmon covers several closely related preparations of placental origin that have been used in Japan for several decades.
Composition and standardisation
Unlike an ordinary medicine, this is not one active molecule with a precisely defined target. Its action is attributed to a set of components: amino acids, short peptides, nucleotides and vitamin derivatives.
Among the amino acids present are glycine and proline, which are part of collagen, as well as lysine, leucine, valine and other essential amino acids. They serve as material for protein synthesis in tissues.
The composition of placental hydrolysates depends on the starting material and the manufacturing process. Reviews note that different makers obtain preparations with a differing profile of components, so results from one study cannot be transferred automatically to another product.
Approved uses
In Japanese labelling the medicine is listed above all for climacteric disorders and for insufficient milk production during lactation. In these directions it is used as a supportive measure under medical supervision.
Placental extracts are also studied in other fields: dermatology, fatigue and recovery programmes. Such work mostly belongs to scientific hypotheses and small studies rather than to approved indications.
The cosmetic use common in Asia is not a registered indication. The decision to use the medicine belongs to a physician, based on examination results.
What to keep in mind
Only a healthcare professional performs the administration. The course and the frequency of procedures are set by a physician; a reference page does not establish a treatment regimen.
The medicine is not used with hypersensitivity to placental preparations or their components, during pregnancy or breastfeeding, in acute infectious or inflammatory states, or in oncological disease.
Redness, itching or mild soreness at the injection site are possible. Transient headache and malaise are sometimes noted.
Ampoules are kept in a cool place protected from light and are not used after the expiry date printed on the pack.
Published research
Primary sources, verified against PubMed:
- A Randomized, Multicenter, Double-Blind, Parallel, Non-Inferiority Clinical Study to Compare the Efficacy and Safety of Unicenta and Melsmon for Menopausal Symptom Improvement., PubMed 37629679 (Medicina (Kaunas), 2023).
- Biological effects of human placental extracts - variations in manufacturing methods and compositions., PubMed 41451368 (Front Pharmacol, 2025).
- Human placental extract activates a wide array of gene expressions related to skin functions., PubMed 35773304 (Sci Rep, 2022).
- Human placental extract, melsmon, suppresses stress-induced neuroinflammation and peripheral inflammation in a mouse model of depression., PubMed 42305446 (Front Pharmacol, 2026).
Listed for reference. Publication of a study is not a claim about this particular product.
Precautions
- This is a prescription medicine. A healthcare professional performs the administration; prescribing and monitoring belong to a physician.
- It is not used with hypersensitivity to placental preparations or their components.
- It is contraindicated during pregnancy and breastfeeding.
- It is not used in acute infectious or inflammatory diseases, or in oncological conditions.
- Redness, itching and soreness at the injection site are possible. Marked reactions should be reported to a doctor.
- Tell your doctor about every medicine you take, your allergies and past illnesses.
- Store in a cool place protected from light, out of the reach of children.
Frequently asked
Is Melsmon a prescription medicine?
Yes. In Japan it is a prescription medicine and is not intended for self-medication.
Can it be used at home on one's own?
No. The solution is administered by healthcare professionals. The schedule of procedures is set by a physician.
Is it a cosmetic product?
No. The cosmetic use of placental extracts is not a registered indication; the product is a medicine.
Where does the order ship from?
Shipping and customs handling are described on the APV Pharmacy delivery page.