Neogra Oral Jelly 100 mg, 7 sachets: profile, composition and research
Reference page for Neogra Oral Jelly 100 mg, 7 sachets. Active substance: Силденафил / Sildenafil.
- What it is: sildenafil in an oral gel form, a PDE5 inhibitor.
- Presentation: 100 mg gel sachets, 7 sachets per pack.
- Status: prescription-only medicine.
- Research: work on sildenafil efficacy and comparisons with tadalafil, links below.
- Where to buy: APV Pharmacy (price and availability there).
Key facts
| Active substance | Sildenafil |
|---|---|
| Form | Oral gel in sachets |
| Strength | 100 mg per sachet |
| Pack size | 7 sachets |
| Category | Prescription medicine |
| Article (SKU) |
What sildenafil is
Sildenafil is the active substance known from tablet products for men. Here it comes in a different form: a gel in single sachets that is squeezed into the mouth and swallowed.
The gel form suits those who find tablets hard to swallow and those for whom speed of absorption matters. The contents dissolve in the mouth and are partly absorbed there, which sets this option apart from a conventional tablet.
The substance belongs to the PDE5 inhibitor class. A pack holds 7 sachets of 100 mg. The sachets come in several flavours, which makes taking them less unpleasant.
How sildenafil works
The physiology of erection
With arousal, nitric oxide is released in the tissues of the penis. It starts a chain of reactions that produces cyclic guanosine monophosphate, which relaxes the smooth muscle of the vessels and increases blood inflow.
The role of PDE5
The enzyme phosphodiesterase type 5 breaks that messenger down and returns the vessels to their resting state. Sildenafil blocks the enzyme, so the signal lasts longer.
What matters here
The medicine does not produce an erection on its own: natural sexual stimulation is required for it to work. It is neither a hormone nor a drug that raises desire.
Approved uses
The main indication for this form is erectile dysfunction in adult men. The condition is often linked to vascular, endocrine and neurological causes, so a doctor should establish where it comes from.
As a substance, sildenafil is also registered for another use: pulmonary arterial hypertension, although different strengths and dosage forms are used there. Substituting one option for the other is not acceptable.
Prescribing the medicine, choosing the form and monitoring tolerability belong to a physician. Before treatment starts, cardiovascular status needs to be assessed.
What to keep in mind
The medicine must not be taken together with nitrates or with certain drugs for pulmonary hypertension: that combination causes a dangerous drop in blood pressure. A doctor has to know about it before prescribing.
Common reactions include headache, flushing, nasal congestion and indigestion. Rarely, sudden worsening of vision or hearing occurs, as does a prolonged painful erection, which is a medical emergency.
Caution is needed after a recent heart attack or stroke, in severe heart, liver or kidney disease, and with low blood pressure. Tell your doctor about every medicine you take, including blood-pressure drugs.
Published research
Primary sources, verified against PubMed:
- Safety and efficacy of sildenafil citrate in the treatment of male erectile dysfunction., PubMed 9916601 (Clinical therapeutics, 1998).
- Direct comparison of tadalafil with sildenafil for the treatment of erectile dysfunction: a systematic review and meta-analysis., PubMed 28741090 (International urology and nephrology, 2017).
- Efficacy and safety of long-term tadalafil 5 mg once daily combined with sildenafil 50 mg as needed at the early stage of treatment for patients with erectile dysfunction., PubMed 24387078 (Andrologia, 2015).
Listed for reference. Publication of a study is not a claim about this particular product.
Precautions
- This is a prescription medicine. Prescribing and monitoring belong to a physician.
- It must not be combined with nitrates or with certain drugs for pulmonary hypertension: a dangerous fall in blood pressure is possible.
- Before treatment starts, a doctor assesses the heart and blood vessels, especially after a heart attack or stroke.
- Severe liver or kidney disease, as well as a tendency to low blood pressure, calls for caution and medical supervision.
- Tell your doctor about every medicine you take, including blood-pressure drugs: interactions are possible.
- Sudden worsening of vision or hearing, and a prolonged painful erection, require urgent medical help.
Frequently asked
Is Neogra Oral Jelly a prescription medicine?
Yes. Sildenafil is a prescription medicine, and a doctor decides on its use.
How does the gel differ from tablets?
In its dosage form. The contents of the sachet are squeezed into the mouth, dissolve and are partly absorbed there. The active substance is the same.
Why does this page not give a dosing schedule?
The dose and the regimen depend on health status and the medicines you take. That is a physician's decision, not a reference page's.
Where does the order ship from?
Shipping and customs handling are described on the APV Pharmacy delivery page.